We hope the findings of this project lead to the implementation of the Choose To Move program into community settings in NSW to increase participation in physical activity by people aged 60+ years. Choose To Move is a community-based program co-designed with older adults and community partners in Canada that increases physical activity and mobility and reduces social isolation. Choose To Move integrates behaviour change principles into two components: activity coaches deliver eight motivational group meetings and conduct one, one-on-one action planning meeting with each participant during the 3-month program. The aim of this project is to adapt the Choose To Move program to the Sydney context. Evaluation will include: 1. Assessment of implementation strategies and indicators to identify factors contributing to implementation effectiveness; 2. Measure if the Choose To Move program benefits health outcomes (e.g., physical activity, mobility, social isolation) in community-dwellers aged 60+ years in Sydney. Principal Investigator: Professor Anne Tiedemann (IMH) Investigators: Professor Heather McKay (University of British Columbia, Canada), Professor Cathie Sherrington (IMH), Associate Professor Leanne Hassett (IMH), Prof Luke Wolfenden (University of Newcastle), Emeritus Professor Adrian Bauman (The University of Sydney), , Professor Philayrath Phongsavan (University of Sydney), Professor Ben Smith (University of Sydney), Dr Juliana Oliveira (IMH), Dr James Kite (University of Sydney), Adrian Prakash (SHARE), Associate Professor Dawn Mackey (Simon Fraser University, Canada), Joanie Sims Gould (University of British Columbia, Canada), Dr Bernadette Brady (University of Sydney). The sponsor of this trial is The University of Sydney. Funding is from the National Health and Medical Research Council.

We hope the findings of this project lead to the implementation of a remotely delivered information and support program that is effective in improving physical activity and other physical and mental health outcomes in women aged 50+ years. The aim of this project is to evaluate the effectiveness and cost-effectiveness of the Active Women over 50 program for increasing physical activity compared with a no intervention wait-list, among 1000 women aged 50+ in urban and rural/regional/remote NSW. Participants will be randomly allocated to one of two groups. Group one will receive access to the Active Women over 50 program including a tailored website, telephone health coaching, SMS/email-based messages and Facebook group, to provide support, motivation and guidance on increasing physical activity. Group two will be placed on a waitlist and receive access to the Active Women over 50 program after the 6 month follow-up. Principal Investigator: Professor Anne Tiedemann (IMH) Investigators: Professor Cathie Sherrington (IMH), Associate Professor Leanne Hassett (IMH), Professor Philayrath Phongsavan (University of Sydney), Emeritus Professor Adrian Bauman (University of Sydney), Dr Abigail Haynes (University of Sydney), Dr Marina de Barros Pinheiro (University of Sydney), Dr Dominika Kwasnicka (University of Melbourne), Professor Nehmat Houssami (University of Sydney), Associate Professor Simon Rosenbaum (University of New South Wales), Associate Professor Georgina Luscombe (University of Sydney), Dr Heidi Gilchrist (University of Sydney), Geraldine Wallbank (University of Sydney), Dr Grace McKeon (University of New South Wales), Professor Kirsten Howard (University of Sydney), Dr Raaj Kishore Biswas (SLHD), Susan Linney (consumer advisor), Trish Stabback (consumer advisor CWA NSW), Kamilla Haufort (consumer advisor COTA NSW). The sponsor of this trial is The University of Sydney. Funding is from the Medical Research Future Fund.

We hope the findings of this project lead to the development of a dance program that is effective in preventing falls among people aged 60+ years. RIPE Dance (Really Is Possible for Everyone), provides popular, long-running tailored dance programs, with a fall prevention focus, for over 100 older people in Southeast Queensland. We plan to conduct a pilot RCT of RIPE dance classes for community-dwelling people aged 60+. The objective is to test the feasibility, acceptability, and intervention impact of the RIPE dance classes. The results will inform the design and methods for a planned large trial of tailored dance classes for older people, with falls as the primary outcome. Principal Investigator: Dr Heidi Gilchrist (IMH) Investigators: Professor Anne Tiedemann (IMH), Professor Cathie Sherrington (IMH), Dr Abigail Haynes (University of Sydney), Dr Juliana Oliveira (IMH), Professor Dafna Merom (Western Sydney University). The sponsor of this trial is The University of Sydney. Funding is from the Physiotherapy Research Foundation.

Visually impaired older people are increasing in number, have significant morbidity but are neglected when it comes to a specific falls prevention strategy. The intention of the trial is to validate the new falls prevention program – Exercise (LiFE) – for visually impaired older people. The PlaTFORM Trial aims to evaluate the effectiveness of the Exercise (LiFE) program to prevent falls and improve function in older people with vision impairment compared to usual care. Participants will be randomised to receive either the LiFE intervention or usual care. The LiFE intervention will be delivered by Guide Dogs’ Orientation and Mobility Instructors. Falls will be reported on a monthly bases and physical activity will be measured at the start of the trial, 3 months and 12 months. This study is currently recruiting. You may be eligible to participate in the study if you are: a client of Guide Dogs NSW/ACT with vision impairment severe enough to interfere with activities of daily living; aged 50 years or older; living in the community or self-care unit of a retirement village; able to understand English well enough to undertake study procedures; no more than two errors on the Short Portable Mental Status Questionnaire; no diagnosis of dementia; and not scheduled for cataract surgery in the next 12 months. Principal Investigator: Associate Professor Lisa Keay Institute for Musculoskeletal Health Investigator: Professor Anne Tiedemann For more information on this George Institute for Global Health trial, please contact: Kirsten Jakobsen e: kjakobsen@georgeinstitute.org.au Trial registered on ANZCTR: ACTRN12616001186448 This NHMRC trial has received ethics approval from the University of Sydney Human Research Ethics Committee.

This project will provide the first robust evidence on the effectiveness of opioids in the treatment of acute low back pain and neck pain. The trial results will improve care for patients suffering acute spinal pain. Low back pain and neck pain place an enormous burden on patients and health services, both nationally and internationally. Despite the widespread use and recommendations in clinical guidelines, there are no randomised controlled trials that have assessed the effectiveness of opioids for acute low back and neck pain. OPAL is a clinical trial to find out whether opioid analgesics are effective in reducing low back or neck pain, compared to placebo. The opioid analgesic medication– oxycodone – will be taken for up to six weeks. During these six weeks, the participant will be reviewed weekly by a treating physician. This study is currently recruiting. You may be eligible to participate if you have experienced low back pain and/or neck pain of at least moderate severity within the last 12 weeks, and are considered by your treating doctor as appropriate for opioid analgesia. Principal Investigator: Professor Christine Lin Chief Investigators: Professor Chris Maher, Professor Jane Latimer, Associate Professor Laurent Billot, Professor Andrew McLachlan, Professor Ric Day and Professor Bart Koes. The sponsor of this trial is the George Institute. The study has received ethics approval from the University of Sydney Human Research Ethics Committee. For more information, please contact the OPAL team. e: sph.opal@sydney.edu.au Trial registered on ANZCTR: ACTRN12615000775516

We hope the findings of this project will lead to improved physical activity levels in people living with moderate to severe traumatic brain injury (TBI). The aim of this project is to develop clinical practice guidelines for physical activity in people across all ages living with moderate-to-severe traumatic brain injury (TBI) in Australia. A plan will also be developed for the effective implementation of these guidelines. The first stage involves evaluating the fit of the 2020 WHO physical activity and sedentary behaviour guidelines for people living with disability to those living with a moderate-to-severe TBI. This includes considering the evidence available regarding physical activity in TBI, preferences for physical activity, perspectives of relevant stakeholders and the feasibility of guideline implementation. Stage two involves auditing brain injury rehabilitation services across Australia to understand how physical activity is delivered and promoted to identify current practice and where practice inconsistencies exist. The third stage involves adapting the WHO guidelines into national clinical practice guidelines for people living with TBI, informed from stages one and two. The final stage involves the development of a plan for implementation of these national practice guidelines based on the identification of barriers and facilitators. Principle Investigator: A/Prof Leanne Hassett Co-Investigators: Prof Gavin Williams (UniMelb); Prof Cathie Sherrington (USyd); A/Prof Sean Tweedy (UQ); Prof Luke Wolfenden (UniNewcastle); Prof Maria Crotty (Flinders); Prof Kirsten Howard (USyd); Dr Abby Haynes (USyd); Emeritus Prof Adrian Bauman (USyd); A/Prof Grahame Simpson (USyd); A/Prof Adam Scheinberg (MCRI); Prof Anne Tiedemann (USyd); Gabrielle Vassallo (consumer representative); Nick Rushworth (BIA) Collaborating Organisations: Brain Injury Australia, Connectivity TBI; icare NSW; Heads Together for ABI Research team: Dr Liam Johnson (UniMelb); Sakina Chagpar (USyd); Belinda Wang (USyd) Funding: MRFF 2020 Traumatic Brain Injury Mission, Stream 2-incubator 2021-2023.

We hope the findings of this project lead to the development of home-based exercise programs to improve strength, balance and reduce falls and improve shoulder functioning in older people. The aim of this project is to compare the effectiveness of two home-based exercise programs – one aimed at improving lower limb strength and balance for preventing falls and the other aimed at improving upper limb strength and mobility to reduce shoulder dysfunction. Participants are taught the exercises in a group workshop setting and then complete their exercises at home three times each week for 12 months. Participants are provided with a calendar to record their exercises and falls each month, and a program manual and exercise weights. This project is no longer recruiting. Principal Investigator: Professor Cathie Sherrington. Chief Investigators: Dr Susan Furber, Professor Anne Tiedemann, Professor Kirsten Howard, Professor Adrian Bauman, Associate Professor Karen Ginn and Dr Paul Van Den Dolder. This project has received ethics approval from the University of Wollongong and Illawarra Shoalhaven Local Health District. This is a NHMRC Partnership Grant (2014 – 2019). For more information about this project, please contact: Professor Cathie Sherrington e: cathie.sherrington@sydney.edu.au Trial registered on ANZCTR: ACTRN12615000865516

We hope the findings of this project lead to increased physical activity, decreased risk of falling and improved eating habits in older people. The aim is to evaluate the effectiveness of two 12 month healthy ageing strategies among people who attend established, community-based groups. The first intervention is a physical activity and fall prevention intervention, including telephone-based health coaching and written information on physical activity and falls. The second is a nutrition intervention involving telephone-based health coaching and written information about eating habits. The trial also aims to establish the impact of these interventions on physical activity, eating habits, weight (body mass index), goal attainment, mobility confidence, quality of life, fear of falling, risk-taking behaviour, well-being, and mood. This project is no longer recruiting. Principal Investigator: Professor Cathie Sherrington. Chief Investigators: Professor Anne Tiedemann, Professor Dafna Merom, Professor Stuart Smith, Associate Professor Allison Tong, Professor Kirsten Howard and Professor Chris Rissel. This project has received ethics approval from the University of Sydney Human Research Ethics Committee. This is a NHMRC Project Grant (2015 – 2018). For more information about this project, please contact: Associate Professor Anne Tiedemann e: anne.tiedemann@sydney.edu.au Trial registered on ANZCTR: ACTRN12615001190594

We hope the findings of this project lead to the development of a yoga-based exercise program to prevent falls in people aged 65 and over. The aim of this project is to assess the effectiveness of a 40 week yoga program, compared with an advice booklet, on falls. We will also assess the effectiveness of the program on other key indicators of healthy ageing, such as mental health, establish the cost-effectiveness of the intervention, and measure the yoga program’s potential for implementation. Participants allocated to the yoga-based exercise group will attend 40 weeks of twice-weekly, one-hour yoga classes in established yoga studios in Sydney with experienced yoga teachers. Participants will be asked to complete a home-based yoga program for at least two extra 20-minute sessions each week. This project is currently recruiting. For more information about this project, please contact us at sph.sagetrial@sydney.edu.au Principal Investigator: Professor Anne Tiedemann (IMH) Chief Investigators: Professor Cathie Sherrington (IMH), Professor Stephen Lord (NeuRA) Associate Investigators: Professor Kirsten Howard (University of Sydney), Professor Adrian Bauman (University of Sydney), Professor Chris Rissel (University of Sydney), Professor Robert Cumming (University of Sydney), Professor Kaarin Anstey (NeuRA), Professor Roberta Shepherd (University of Sydney), Associate Professor Patrick Kelly (University of Sydney), Dr Anne Grunseit (University of Sydney), Romina Sesto This project has received ethics approval. The sponsor of this trial is The University of Sydney. Funding is from the National Health and Medical Research Council.

We hope the findings of this project lead to enhanced promotion of physical activity by health professionals for people aged 50+ and people of all ages with a physical disability. The aim of the project is to determine whether a health professional education and support package (workshop, website, on-line discussion, phone/email support) increases promotion of physical activity and frequency of recommendations about attendance at community-based structured physical activity opportunities among people aged 50+ and/or people of any age with physical disabilities compared with waiting list control. This project is currently recruiting. Chief Investigator: Professor Cathie Sherrington (IMH) Associate Investigators: Professor Anne Tiedemann (IMH), Dr Leanne Hassett (IMH), Dr Bethan Richards (IMH), Professor Louise Baur (The Children’s Hospital at Westmead & The University of Sydney), Professor Adrian Bauman (The University of Sydney), Professor Lisa Harvey (The University of Sydney), Associate Professor Philayrath Phongsavan (University of Sydney), Professor Jennifer Alison (University of Sydney), Associate Professor Ben Smith (University of Sydney), Kate Purcell (IMH), Jenni Cole (Disability Sports Australia), Professor Chris Rissel (University of Sydney & the NSW Office of Preventive Health), Associate Professor Jeff Walkley (Belgravia Leisure), Dr Genevieve Dwyer (Western Sydney University), Kerry West (IMH). This project has received ethics approval from Local Health District Ethics Committees and is being funded by Medical Research Future Fund (MRFF) Rapid Applied Research Translation Grant. For more information about this project, please contact: Kate Purcell e: kate.purcell@sydney.edu.au

We hope the findings of this project lead to understanding of health professional promotion of parkrun to patients in Australia to help more Australians become active more often. The aim of the project is to undertake qualitative research with a range of health practitioners as well as with people who lead local parkrun events to explore greater health professional promotion of parkrun in Australia. Parkrun organise free, weekly, timed 5 km events in parks all around the world. To encourage patients to become more active, a number of general practice surgeries in the United Kingdom have become parkrun practices. In parkrun practices, health practitioners direct suitable patients to local parkrun events and encourage them to participate or volunteer. This project will explore the use of similar approaches in Australia. Principal investigator: Dr Stephen Gilbert (IMH) Chief Investigator: Prof. Cathie Sherrington (IMH) Associate Investigators: Prof. Anne Tiedemann (IMH), Dr Anne Grunseit (University of Sydney), Dr Lindsey Reece (University of Sydney). This project has received ethics approval from the University of Sydney Human Research Ethics Committee. For more information about this project, please contact: Dr Stephen Gilbert e: stephen.gilbert@sydney.edu.au

The aim of this trial is to assess the effectiveness of the Ironbark fall prevention program on reducing the number of falls in Aboriginal and Torres Strait Islander people who are 45 years and older. This group is compared to control participants who receive a healthy ageing program. The Ironbark program includes interactive discussion about fall risk factors, combined with balance and strength training. It was created after a successful New South Wales pilot and will now run across New South Wales, South Australia and Western Australia. This study is not yet recruiting participants. Principal Investigator: Professor Rebecca Ivers Institute for Musculoskeletal Health Investigators: Professor Cathie Sherrington and Professor Anne Tiedemann This study is funded through the NHMRC. For more information on this George Institute for Global Health trial, please contact: Dr Julieann Coombes w: https://www.georgeinstitute.org.au/people/julieann-coombes